A heterogeneous tissue model for treatment planning for magnetic resonance-guided laser interstitial thermal therapy. (3rd October 2018)

• Record Type: Journal Article
• Authors: Mitchell, Drew; Fahrenholtz, Samuel; MacLellan, Christopher; Bastos, Dhiego; Rao, Ganesh; Prabhu, Sujit; Weinberg, Jeffrey; Hazle, John; Stafford, Jason; Fuentes, David
• Is Part Of: International journal of hyperthermia. Volume 34:Number 7(2018)
• Page Start: 943
• Page End: 952
• Publication Date: 2018-10-03
• Subjects: MR thermometry -- laser interstitial thermal therapy -- thermal ablation -- inverse problems -- Pennes bioheat model; Thermotherapy -- Periodicals; 615.832
• DOI: 10.1080/02656736.2018.1429679
• Languages: English
• ISSNs: 0265-6736

Abstract

Abstract: We evaluated a physics-based model for planning for magnetic resonance-guided laser interstitial thermal therapy for focal brain lesions. Linear superposition of analytical point source solutions to the steady-state Pennes bioheat transfer equation simulates laser-induced heating in brain tissue. The line integral of the photon attenuation from the laser source enables computation of the laser interaction with heterogeneous tissue. Magnetic resonance thermometry data sets ( n = 31) were used to calibrate and retrospectively validate the model's thermal ablation prediction accuracy, which was quantified by the Dice similarity coefficient (DSC) between model-predicted and measured ablation regions ( T > 57 °C). A Gaussian mixture model was used to identify independent tissue labels on pre-treatment anatomical magnetic resonance images. The tissue-dependent optical attenuation coefficients within these labels were calibrated using an interior point method that maximises DSC agreement with thermometry. The distribution of calibrated tissue properties formed a population model for our patient cohort. Model prediction accuracy was cross-validated using the population mean of the calibrated tissue properties. A homogeneous tissue model was used as a reference control. The median DSC values in cross-validation were 0.829 for the homogeneous model and 0.840 for the heterogeneous model. In cross-validation, the heterogeneous model produced a DSC higher than that produced by the homogeneous model in 23 of the 31 brain lesion ablations. Results of a paired, two-tailed Wilcoxon signed-rank test indicated that the performance improvement of the heterogeneous model over that of the homogeneous model was statistically significant ( p < 0.01).