Drug use patterns predict risk of non-fatal overdose among street-involved youth in a Canadian setting. (1st August 2015)

• Record Type: Journal Article
• Authors: Mitra, Goldis; Wood, Evan; Nguyen, Paul; Kerr, Thomas; DeBeck, Kora
• Is Part Of: Drug and alcohol dependence. Volume 153(2015)
• Page Start: 135
• Page End: 139
• Publication Date: 2015-08-01
• Subjects: Illicit drug use -- Prescription opiate use -- Prescription drug use -- Injection drug use -- Street-involved youth -- Non-fatal drug overdose; Drug abuse -- Periodicals; Alcoholism -- Periodicals; 616.86
• DOI: 10.1016/j.drugalcdep.2015.05.035
• Languages: English
• ISSNs: 0376-8716

Abstract

Highlights: We examined the risk factors associated with non-fatal drug overdose among youth. Binge drug use and illicit drug use were found to be associated with risk of overdose. Prescription opiate use, which is increasing among youth, was also associated with overdose. Comprehensive interventions to address illicit and prescription drug use among youth are needed. Abstract: Background: Non-fatal drug overdose is a major cause of morbidity among people who use drugs, although few studies have examined this risk among street-involved youth. We sought to determine the risk factors associated with non-fatal overdose among Canadian street-involved youth who reported illicit drug use. Methods: Using data from a prospective cohort of street-involved youth in Vancouver, Canada, we identified youth without a history of overdose and employed Cox regression analyses to determine factors associated with time to non-fatal overdose between September 2005 and May 2012. Results: Among 615 participants, 98 (15.9%) reported a non-fatal overdose event during follow-up, resulting in an incidence density of 7.67 cases per 100 person-years. In multivariate Cox regression analyses, binge drug use (adjusted hazard ratio [AHR] = 1.85; 95% confidence interval [CI] = 1.20–2.84), non-injection crystal methamphetamine use (AHR = 1.70; 95% CI = 1.12–2.58), non-injection prescription opiate use (AHR = 2.56; 95% CI = 1.36–4.82), injection prescription opiate use (AHR = 2.49; 95% CI = 1.40–4.45) and injection heroin use (AHR = 1.85; 95% CI = 1.14–3.00) were positively associated with time to non-fatal overdose. Social, behavioural and demographic factors were not significantly associated with time to non-fatal overdose event. Conclusions: Rates of non-fatal overdose were high among street-involved youth. Drug use patterns, in particular prescription opiate use, were associated with overdose. These findings underscore the importance of addiction treatment and prevention efforts aimed at reducing the risk of overdose among youth.