Fabrication of biomimetic polysiloxane-bioactive glass–chitosan hybrid monoliths with high apatite-forming bioactivity. (July 2015)

• Record Type: Journal Article
• Authors: Chen, Jing; Que, Wenxiu; Xing, Yonglei; Lei, Bo
• Is Part Of: Ceramics international. Volume 41(2015)Supplement 1
• Page Start: S393
• Page End: S398
• Publication Date: 2015-07
• Subjects: A. Sol–gel process -- Bioactive glass -- Chitosan -- Apatite-forming bioactivity; Ceramics -- Periodicals; Céramique industrielle -- Périodiques; Ceramics; Periodicals; Electronic journals; 666
• DOI: 10.1016/j.ceramint.2015.03.261
• Languages: English
• ISSNs: 0272-8842

Abstract

Abstract: The development of biomimetic hybrid implants with high bioactivity is very important for successful bone tissue regeneration. This paper presents a simple strategy for fabricating polydimethylsiloxane–bioactive glass–chitosan hybrid monoliths by a facile sol–gel process. Here, chitosan, which is a critical component in human body, is a natural biocompatible polymer and glycosaminoglycans. Our results indicate that the as-fabricated hybrid monoliths have a porous structure and crack-free morphology, and the in vitro bioactivity test demonstrates that the novel hybrid monoliths have a high apatite-forming ability in simulated body fluid. The facile synthesis, biomimetic structure and composition, as well as high bioactivity of the as-fabricated hybrid monoliths make them promising materials for applications in bone tissue regeneration.