Novel oligopeptide nanoprobe for targeted cancer cell imaging. Issue 54 (3rd September 2018)

• Record Type: Journal Article
• Authors: Ding, Wen-Qiang; Qin, Si-Yong; Cheng, Yin-Jia; Ma, Yi-Han; Zhang, Ai-Qing
• Is Part Of: RSC advances. Volume 8:Issue 54(2018)
• Page Start: 30887
• Page End: 30893
• Publication Date: 2018-09-03
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c8ra06034g
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Co-assembly of WFFW tetrapeptide and RGDWFFW heptapeptide generated the photostable and fluorescence-tunable nanoprobe, which could selectively image the cancer cells. Abstract : Here we designed and constructed a tryptophan-phenylalanine-phenylalanine-tryptophan (WFFW) tetrapeptide, which generated photostable and tunable fluorescence emission signals from 340 nm to 500 nm. The WFFW tetrapeptide could self-assemble into a spherical nanostructure with enhanced fluorescence intensity. Driven by π–π stacking and hydrogen bond interaction, WFFW co-assembled with arginine-glycine-aspartic acid (RGD) modified WFFW to form a cancer-targeted fluorescent nanoprobe, which could selectively image the cancer cells.