Implantable biosensors and their contribution to the future of precision medicine. (September 2018)

• Record Type: Journal Article
• Authors: Gray, M.; Meehan, J.; Ward, C.; Langdon, S.P.; Kunkler, I.H.; Murray, A.; Argyle, D.
• Is Part Of: Veterinary journal. Volume 239(2018)
• Page Start: 21
• Page End: 29
• Publication Date: 2018-09
• Subjects: Cancer -- Foreign body response -- Implantable biosensors -- Precision medicine; Veterinary medicine -- Periodicals; 636
• DOI: 10.1016/j.tvjl.2018.07.011
• Languages: English
• ISSNs: 1090-0233

Abstract

Highlights: Precision medicine takes individual variability into account in disease management. Implantable biosensors have important applications in precision medicine. Biosensors can provide continuous data enabling trends to be monitored. Immune response must be evaluated for implantable devices to be used clinically. Abstract: Precision medicine can be defined as the prevention, investigation and treatment of diseases taking individual variability into account. There are multiple ways in which the field of precision medicine may be advanced; however, recent innovations in the fields of electronics and microfabrication techniques have led to an increased interest in the use of implantable biosensors in precision medicine. Implantable biosensors are an important class of biosensors because of their ability to provide continuous data on the levels of a target analyte; this enables trends and changes in analyte levels over time to be monitored without any need for intervention from either the patient or clinician. As such, implantable biosensors have great potential in the diagnosis, monitoring, management and treatment of a variety of disease conditions. In this review, we describe precision medicine and the role implantable biosensors may have in this field, along with challenges in their clinical implementation due to the host immune responses they elicit within the body.