Temporal trends of perfluorooctanesulfonate isomer and enantiomer patterns in archived Swedish and American serum samples. (February 2015)

• Record Type: Journal Article
• Authors: Liu, Yanna; Pereira, Alberto S.; Beesoon, Sanjay; Vestergren, Robin; Berger, Urs; Olsen, Geary W.; Glynn, Anders; Martin, Jonathan W.
• Is Part Of: Environment international. Volume 75(2015:Feb.)
• Page Start: 215
• Page End: 222
• Publication Date: 2015-02
• Subjects: Perfluorooctanesulfonate (PFOS) -- Perfluorooctanesulfonate precursors (PreFOS) -- Isomers -- Enantiomers -- Temporal trends -- Human exposure; Environmental protection -- Periodicals; Environmental health -- Periodicals; Environmental monitoring -- Periodicals; Environmental Monitoring -- Periodicals; Environnement -- Protection -- Périodiques; Hygiène du milieu -- Périodiques; Environnement -- Surveillance -- Périodiques; Environmental health; Environmental monitoring; Environmental protection; Periodicals; 333.705
• DOI: 10.1016/j.envint.2014.11.014
• Languages: English
• ISSNs: 0160-4120

Abstract

Abstract: Human perfluorooctanesulfonate (PFOS) body burdens are attributable to both direct PFOS and indirect PFOS precursor (PreFOS) exposure. The relative importance of these two pathways has been estimated, but the relative temporal trajectory of exposure to PFOS and PreFOS has not been examined. Here, two hypothesized biomarkers of PreFOS exposure, PFOS isomer profiles (quantified as percent branched PFOS, %br-PFOS) and chiral 1 m -PFOS enantiomer fractions (1 m -PFOS EF) were analyzed in archived human serum samples of individual American adults (1974–2010) and pooled samples of Swedish primiparous women (1996–2010). After correcting for potential confounders, significant correlations between %br-PFOS and 1 m -PFOS EFs were observed in American samples and in Swedish samples for the 1996–2000 period, supporting the hypothesis that both %br-PFOS and 1 m -PFOS EF are biomarkers of PreFOS exposure. Significant trends of increasing %br-PFOS, from 2000 to 2010, and increasingly non-racemic 1 m -PFOS EFs, from 1996 to 2000, were detected in Swedish samples. No statistically significant trend for %br-PFOS or 1 m -PFOS EF was observed in American samples, but American males had significantly higher %br-PFOS and significantly lower 1 m -PFOS EF (i.e. more non-racemic) than females, and a similar significant difference was shown in the older age group, relative to the younger age group. These temporal trends in %br-PFOS and 1 m -PFOS EF are not easily explained and the results highlight uncertainties about how humans are exposed to PFOS. Graphical abstract: Highlights: Both PFOS isomer and enantiomer profiles were measured in archived human sera. Both biomarkers suggested an increase in relative PreFOS exposure in Swedish women. Two biomarkers were correlated in Swedes (1996–2000) and in Americans (1974–2010). Age and gender differences for both biomarkers were detected in Americans.