A study of difference in serum 25-hydroxyvitamin D concentrations in patients with angiographically-defined coronary disease and healthy subjects. Issue 5 (September 2018)

• Record Type: Journal Article
• Authors: Rokni, Haleh; Moohebati, Mohsen; Saberi-Karimian, Maryam; Mirhafez, Seyed Reza; Ghazizadeh, Hamideh; Laal-Vazifeh, Atieh; Shekari, Maryam; Movahhedianfar, Faezeh; Mazidi, Mohsen; Bonakdaran, Shokoufeh; Ferns, Gordon A.; Ghayour-Mobarhan, Majid
• Is Part Of: Diabetes & metabolic syndrome. Volume 12:Issue 5(2018)
• Page Start: 683
• Page End: 687
• Publication Date: 2018-09
• Subjects: 25OHD -- Phosphate -- Calcium -- Angiography -- Coronary artery disease; Diabetes -- Periodicals; Metabolism -- Disorders -- Periodicals; Diabetes Mellitus -- Periodicals; Metabolic Diseases -- Periodicals; Diabète -- Périodiques; Métabolisme, Troubles du -- Périodiques; Endocrinologie -- Périodiques; Diabète -- Physiopathologie -- Périodiques; Diabetes; Metabolism -- Disorders; Electronic journals; Periodicals; 616.462
• DOI: 10.1016/j.dsx.2018.04.006
• Languages: English
• ISSNs: 1871-4021

Abstract

Abstract: Background: Cardiovascular disease (CVD) is one of the most important causes of death in developing countries. The current study evaluates the serum 25-hydroxyvitamin D (25OHD), phosphate and calcium levels in patients with angiographically-defined coronary artery disease (CAD) and healthy subjects in a sample population in northeastern Iran. Methods: There were 566 subjects aged between 20–80 years out of whom283 subjects with CAD were divided into two study groups based on their angiogram results; those with > 50% stenosis of one or more coronary arteries and those with ≤ 50% stenosis. Serum 25OHD levels and anthropometric parameters were measured for all subjects. Results: There were approximately 53% (n = 303) males and 47% (n = 269) females in the population sample. We found that crude serum 25OHD concentrations were significantly higher in both the Angio − (21.6 ± 11.8 ng/ml) and Angio + (21.3 ± 10.2 ng/ml) groups compared to the control subjects (16.4 ± 9.5 ng/ml) (P < 0.001). Conclusion: The findings show that 25OHD state could be a risk factor for CAD, although this would need to be explored further, taking the potential confounding effects of diet into account in future studies.