Risk of Cognitive Decline Associated With Paroxetine Use in Elderly Nursing Home Patients With Depression. (December 2016)

• Record Type: Journal Article
• Authors: Bali, Vishal; Chatterjee, Satabdi; Johnson, Michael L.; Chen, Hua; Carnahan, Ryan M.; Aparasu, Rajender R.
• Is Part Of: American journal of Alzheimer's disease & other dementias. Volume 31:Number 8(2016)
• Page Start: 678
• Page End: 686
• Publication Date: 2016-12
• Subjects: cognition -- paroxetine -- depression -- elderly; Alzheimer's disease -- Periodicals; Dementia -- Periodicals; Alzheimer's disease -- Patients -- Care -- United States -- Periodicals; 616.83
• DOI: 10.1177/1533317516673463
• Languages: English
• ISSNs: 1533-3175

Abstract

Objective: This study evaluated the risk of cognitive decline associated with paroxetine use in elderly nursing home patients with depression. Methods: A retrospective cohort study was conducted using the 2007 to 2010 Medicare Part D claims and minimum data set (MDS) data involving new users of paroxetine and other selective serotonin reuptake inhibitors (SSRIs). The primary outcome was MDS Cognition Scale. The repeated-measures mixed model was used to examine the effect of paroxetine on cognition after controlling for other factors. Results: The baseline MDS Cognition Scale measures for paroxetine (n = 63) and other SSRI users (n =1018) were 2.02 (±1.85) and 2.50 (±2.39), respectively. The repeated-measures mixed model did not find statistically significant difference in cognition with the use of paroxetine (β = 0.02, 95% CI: −0.16 to 0.21]) when compared to other SSRIs. Conclusions: There was no differential effect of paroxetine on cognition when compared to other SSRIs.