Enantioselective intermolecular iodoacetalization of enol ethers catalyzed by chiral Co(III)-complex-templated Brønsted acids. Issue 40 (3rd October 2018)

• Record Type: Journal Article
• Authors: Li, Na; Yu, Hao; Wang, Rui; Shen, Jia; Wu, Wen-Qiang; Liu, Kun; Sun, Ting-Ting; Zhang, Zheng-Zhu; Yao, Chuan-Zhi; Yu, Jie
• Is Part Of: Tetrahedron letters. Volume 59:Issue 40(2018)
• Page Start: 3605
• Page End: 3608
• Publication Date: 2018-10-03
• Subjects: Chiral Co(III) complexes -- Brønsted acid -- Intermolecular -- Iodoacetalization; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2018.08.047
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Employing chiral Co(III)-complex-templated Brønsted acids as catalysts. The asymmetric intermolecular iodoacetalization of enol ethers was achieved. This method provided an easy access to optically active 3-iodoacetal derivatives. High yield and up to 83:17 er. Abstract: The chiral Co(III)-complex-templated Brønsted acids were used as efficient bifunctional phase-transfer catalysts for the asymmetric intermolecular iodoacetalization of enol ethers, such as 3, 4-dihydro-2H-pyran, 2, 3-dihydrofuran, ethyl vinyl ether with alcohols and NIS, furnishing the 3-iodoacetals in high yield with up to 83:17 er.