Successful antiretroviral therapy by using unusual antiretroviral combinations in heavily pre-treated patients: two case reports. (October 2015)

• Record Type: Journal Article
• Authors: Taramasso, Lucia; Dentone, Chiara; Alessandrini, Anna; Bruzzone, Bianca; Icardi, Giancarlo; Garraffo, Rodolphe; De Macina, Ilaria; Viscoli, Claudio; Di Biagio, Antonio
• Is Part Of: International journal of STD & AIDS. Volume 26:Number 11(2015:Nov.)
• Page Start: 831
• Page End: 834
• Publication Date: 2015-10
• Subjects: HIV -- AIDS -- antiretroviral therapy -- treatment -- dolutegravir -- darunavir -- treatment experienced -- resistance; Sexually transmitted diseases -- Periodicals; AIDS (Disease) -- Periodicals; 616.951
• DOI: 10.1177/0956462414556330
• Languages: English
• ISSNs: 0956-4624

Abstract

In the context of HIV-infected patients with several past antiretroviral therapies and multiple failures, it is possible to be faced with viruses resistant to all drug classes. We report on two HIV-1 infected patients in which the historical genotype showed mutations against all the major drug classes and in which viral suppression has been obtained by non-conventional antiretroviral therapy regimens, including the combination of darunavir at high dosage (800 mg bid), dolutegravir (50 mg bid) and a third agent, i.e. enfuvirtide in the first case and etravirine in the second one.