1, 1-Diphenyl, 2-picrylhydrazyl free radical scavenging, bactericidal, fungicidal and leishmanicidal properties of Teucrium stocksianum. (November 2015)

• Record Type: Journal Article
• Authors: Shah, Syed Majid; Ayaz, Mohammad; Khan, Arif-ullah; Ullah, Farhat; Farhan, ; Shah, Azhar-ul-Haq Ali; Iqbal, Hamid; Hussain, Sajid
• Is Part Of: Toxicology and industrial health. Volume 31:Number 11(2015)
• Page Start: 1037
• Page End: 1043
• Publication Date: 2015-11
• Subjects: Teucrium stocksianum -- antioxidant -- antibacterial -- antifungal -- antileishmanial; Toxicology, Experimental -- Periodicals; Industrial toxicology -- Periodicals; 615.9
• DOI: 10.1177/0748233713487250
• Languages: English
• ISSNs: 0748-2337

Abstract

In the present study, we evaluated the pharmacological and toxicological effects of Teucrium stocksianum . The crude extract of T. stocksianum (Ts.Cr) and its subsequent organic fractions: n -hexane (Ts.Hex), chloroform (Ts.CHCl3 ) and ethyl acetate (Ts.EtAc) exhibited 1, 1-diphenyl, 2-picrylhydrazyl free radical scavenging activity with different potencies. Ts.EtAc was found to be most potent. Ts.Cr, Ts.Hex, Ts.CHCl3 and Ts.EtAc showed significant bactericidal activity against Escherichia coli, Staphylococcus aureus, Salmonella typhi, Shigella flexneri and Bacillus subtilis at their extent. Ts.Cr, Ts.Hex, Ts.CHCl3 and Ts.EtAc displayed fungicidal action against Aspergillus niger, Aspergillus flavus, Aspergillus fumigatus and Fusarium solani at various minimum inhibitory concentrations. Ts.Cr and Ts.EtAc exhibited marked inhibition of Leishmania tropica growth, observed after 48 and 96 hrs of treatment. These data indicate that the T. stocksianum methanolic extract and its resultant fractions possess antioxidant, antibacterial, antifungal and antileishmanial activities. Thus, the present research unearths the scientific base for T. stocksianum medicinal application as antioxidant and antimicrobial agents.