Lattice percolation approach to numerical modelling of tissue aging. Issue 1 (2nd January 2016)

• Record Type: Journal Article
• Authors: Privman, Vladimir; Gorshkov, Vyacheslav; Libert, Sergiy
• Is Part Of: International journal of parallel, emergent and distributed systems. Volume 31:Issue 1(2016)
• Page Start: 1
• Page End: 19
• Publication Date: 2016-01-02
• Subjects: tissue aging -- percolation model -- senescence; Parallel computers -- Periodicals; Electronic data processing -- Distributed processing -- Periodicals; Computer algorithms -- Periodicals; 004.35
• DOI: 10.1080/17445760.2015.1057588
• Languages: English
• ISSNs: 1744-5760

Abstract

Abstract : We describe a percolation-type approach to modelling of the processes of aging and certain other properties of tissues analysed as systems consisting of interacting cells. Tissues are considered as structures made of regular healthy, senescent, dead (apoptotic) cells, and studied dynamically with the ongoing processes including regular cell division to fill vacant sites left by dead cells, healthy cells becoming senescent or dying, and other processes. Statistical-mechanics description can provide patterns of time dependence and snapshots of morphological system properties. An illustrative application of the developed theoretical modelling approach is reported, confirming recent experimental findings that inhibition of senescence can lead to extended lifespan.