Antimalarial Properties of Morinda lucida and Alstonia boonei on Sulphadoxine-Pyrimethamine and Curcuma longa on Quinine in Mice. Issue 1 (2nd January 2016)

• Record Type: Journal Article
• Authors: Agbedahunsi, Joseph M.; Adepiti, Awodayo O.; Adedini, Adeteju A.; Akinsomisoye, Adetola; Adepitan, Olusegun
• Is Part Of: Journal of herbs, spices & medicinal plants. Volume 22:Issue 1(2016)
• Page Start: 1
• Page End: 10
• Publication Date: 2016-01-02
• Subjects: Plasmodium berghei -- malaria chemosuppression -- in vivo -- four-day malaria test; Medicinal plants -- Periodicals; Herbs -- Periodicals; Spices -- Periodicals; 581.63
• DOI: 10.1080/10496475.2014.999151
• Languages: English
• ISSNs: 1049-6475

Abstract

Abstract : The antimalarial activities of Morinda lucida (MLE), Alstonia boonei (ABE), Curcuma longa (CLE) at 12.5–400 mg kg −1, sulphadoxine-pyrimethamine (S-P), and quinine at 0.2–1.7 and 0.625–10 mg kg −1, respectively, were investigated in Plasmodium berghei –infected mice using the 4-d malaria test. Assessment of MLE plus S-P, ABE plus S-P, and CLE plus quinine was similarly done. Dose-dependent activities were noted with MLE, ABE, and CLE with chemosuppression values of 39.8–90.5, 0.2–74.8, and 34.6–78.4%, respectively. The combinations gave 1.8- to 2.5-fold greater chemosuppression than the individual drug/extracts. The efficacies of S-P and quinine were enhanced when combined with the extracts.