Delayed sleep phase syndrome and bipolar disorder: Pathogenesis and available common biomarkers. (October 2018)

• Record Type: Journal Article
• Authors: Talih, Farid; Gebara, Nour Y.; Andary, Farah S.; Mondello, Stefania; Kobeissy, Firas; Ferri, Raffaele
• Is Part Of: Sleep medicine reviews. Volume 41(2018)
• Page Start: 133
• Page End: 140
• Publication Date: 2018-10
• Subjects: Circadian rhythm sleep-wake disorders -- Bipolar disorder -- Delayed sleep wake phase disorder -- Biomarkers -- Mood disorder -- Sleep disorders -- Melatonin; Sleep disorders -- Periodicals; Sleep Disorders -- Periodicals; Sommeil, Troubles du -- Périodiques; Electronic journals; 616.8498
• DOI: 10.1016/j.smrv.2018.02.002
• Languages: English
• ISSNs: 1087-0792

Abstract

Summary: Circadian rhythm disturbances are common in bipolar affective disorder (BD). Delayed sleep-wake phase syndrome (DSWPD) is the most prevalent circadian rhythm sleep-wake disorder (CRSWDs) and is frequently observed in BD. It is unclear whether DSWPD in BD is an independent process or is a consequence of BD. In this hypothetical review, we discuss the overlap between BD and DSWPD and potential common biomarkers for DSWPD and BD. The review will include a discussion of the genetics of DSWPD and BD. Biomarkers elucidating the pathophysiological processes occurring in these two disorders may offer insight into the etiology and prognosis of both conditions.