Effect of menopausal hormone therapy on components of the metabolic syndrome. (January 2017)

• Record Type: Journal Article
• Authors: Lovre, Dragana; Lindsey, Sarah H.; Mauvais-Jarvis, Franck
• Is Part Of: Therapeutic advances in cardiovascular disease. Volume 11:Number 1(2017)
• Page Start: 33
• Page End: 43
• Publication Date: 2017-01
• Subjects: adiposity -- bazedoxifene -- conjugated estrogen -- diabetes -- insulin resistance -- menopausal hormone therapy -- menopause -- metabolic syndrome; Cardiovascular system -- Diseases -- Periodicals; Cardiovascular system -- Diseases -- Treatment -- Periodicals; Cardiovascular pharmacology -- Periodicals; Cardiovascular Diseases -- diagnosis -- Periodicals; Cardiovascular Diseases -- therapy -- Periodicals; Cardiovascular Agents -- therapeutic use -- Periodicals; Cardiovascular Diseases -- drug therapy -- Periodicals; Cardiovascular System -- drug effects -- Periodicals; Cardiologie; Hart- en vaatziekten; Appareil cardiovasculaire -- Maladies -- Périodiques; Appareil cardiovasculaire -- Maladies -- Traitement -- Périodiques; Pharmacologie cardiovasculaire -- Périodiques; 616.10605
• DOI: 10.1177/1753944716649358
• Languages: English
• ISSNs: 1753-9447

Abstract

The world population is aging, and women will spend an increasing share of their lives in a postmenopausal state that predisposes to metabolic dysfunction. Thus, the prevalence of metabolic syndrome (MetS) in women is likely to increase dramatically. This article summarizes the effects of menopause in predisposing to components of MetS including visceral obesity, dyslipidemia, type 2 diabetes (T2D) and hypertension (HTN). We also summarize the effects of menopausal hormone therapy (MHT) in reversing these metabolic alterations and discuss therapeutic advances of novel menopausal treatment on metabolic function.