Repeated resections for liver metastasis from primary adrenocortical carcinoma: A case report. (2015)

• Record Type: Journal Article
• Authors: Nakano, Ryosuke; Satoh, Daisuke; Nakajima, Hirochika; Yoshimura, Yuri; Miyoshi, Hisanobu; Yoshida, Kazuhiro; Matsukawa, Hiroyoshi; Shiozaki, Shigehiro; Ichimura, Kouichi; Okajima, Masazumi; Ninomiya, Motoki
• Is Part Of: International journal of surgery case reports. Volume 9(2015)
• Page Start: 119
• Page End: 122
• Publication Date: 2015
• Subjects: Adrenal cortical carcinoma -- Liver metastasis -- Resection; Surgery -- Periodicals; Surgical Procedures, Operative -- Periodicals; Surgery; Electronic journals; Periodicals; 617.005
• DOI: 10.1016/j.ijscr.2015.02.041
• Languages: English
• ISSNs: 2210-2612

Abstract

Highlights: Adrenal cortical carcinoma (ACC) is rare, often recurring, and has a poor prognosis. Surgery remains the optimal treatment for ACC, due to chemotherapy's ineffectiveness. Our patient developed 2 liver metastases after right adrenalectomy (1.5 and 4 years). Therefore, complete surgical resection should be considered in similar cases. Abstract: Introduction: Adrenal cortical carcinoma (ACC) is a very rare type of tumor that generally has a poor prognosis. Little has been reported on repeated liver resections with recurrent metastasis still confined to the liver. In this report, we describe a case of functioning ACC in a 65-year-old woman with 2 liver metastases of the ACC (at 1.5 and 4 years) after the right adrenalectomy. Presentation of case: A 65-year-old woman was referred to our hospital based on a suspicion of hyperaldosteronism. Abdominal computed tomography revealed a lesion at the right adrenal gland; therefore, we performed right adrenalectomy and subsequently diagnosed the lesion as ACC. However, follow-up computed tomography at 1.5 and 4 years after the right adrenalectomy revealed liver metastasis of ACC; liver resection was performed for both metastases. Discussion: Complete surgical resection is the established approach for the treatment of ACC. The prognosis of ACC is usually dismal, and recurrence rates of up to 85% have been reported. However, the appropriate treatment for recurrent ACC is not well established, and the effectiveness of other modalities, such as chemotherapy and radiotherapy, is not proven. Therefore, surgical resection may currently be the most appropriate treatment modality, as the patient achieved a disease-free interval of 2.5 years after the first liver resection. Conclusion: In selected patients with recurrent or metastatic ACC, resection is likely to be associated with prolonged survival. However, a full cure is generally not achievable, and a multidisciplinary approach is likely needed to achieve long-term disease-free status and survival.