Comparison of strain measurement from multimodality tissue tracking with strain-encoding MRI and harmonic phase MRI in pulmonary hypertension. (1st March 2015)

• Record Type: Journal Article
• Authors: Ohyama, Yoshiaki; Ambale-Venkatesh, Bharath; Chamera, Elzbieta; Shehata, Monda L.; Corona-Villalobos, Celia P.; Zimmerman, Stefan L.; Hassoun, Paul M.; Bluemke, David A.; Lima, Joao A.C.
• Is Part Of: International journal of cardiology. Volume 182(2015)
• Page Start: 342
• Page End: 348
• Publication Date: 2015-03-01
• Subjects: PH pulmonary hypertension -- RV right ventricle -- LV left ventricle -- HARP harmonic phase analysis -- MTT multimodality tissue tracking -- SENC strain-encoding -- Ell longitudinal strain -- Ecc circumferential strain.; Cardiac magnetic resonance -- Myocardial strain -- Pulmonary hypertension; Cardiology -- Periodicals; Electronic journals; 616.12
• DOI: 10.1016/j.ijcard.2015.01.016
• Languages: English
• ISSNs: 0167-5273

Abstract

Abstract: Background: Pixel-based multimodality tissue tracking (MTT) is a new noninvasive method for the quantification of cardiac deformation from cine image of MRI. The aim of this study is to validate bi-ventricular strain measurement by MTT compared to strain-encoding (SENC) MRI and harmonic phase (HARP) MRI in pulmonary hypertension (PH) patients. Methods: In 45 subjects (30 PH patients and 15 normal subjects), RV and LV peak global longitudinal strains (Ell) were measured from long axis 4 chamber view using MTT. LV peak global circumferential strains (Ecc) by MTT were measured from short axis. For validation, RV and LV Ell by MTT were compared to measures by SENC-MRI from short axis, and LV Ecc by MTT was compared to measures by short axis tagged MRI analysis (HARP). Reproducibility of MTT was also determined. Results: MTT quantified RV Ell correlated closely to those of SENC (r = 0.72, p < 0.001), with good limits of agreement. LV Ell quantified by MTT showed moderate correlation with SENC (r = 0.57, p = 0.001), and LV Ecc by MTT also showed moderate correlation with HARP (− 16.9 ± 4.1 vs − 14.3 ± 3.5, p < 0.001 for all, r = 0.60, p < 0.001). RV Ell negatively correlated with RVEF (r = − 0.53, p = 0.001) and also positively correlated with mean PAP in PH patients (r = 0.60, p = 0.001). Strain measurement by MTT showed high reproducibility. Conclusions: We demonstrate that MTT is a reproducible tool for quantification of cardiac deformation using cine images in PH patients. Hence, it could serve as a new rapid and comprehensive technique for clinical assessment of regional cardiac function. Highlights: Pixel-based multimodality tissue tracking (MTT) is a method to quantify cardiac deformation using CMR cine image. We validated MTT with the well-tested SENC or HARP method in pulmonary hypertension patients. Bi-ventricular strain measures by MTT correlated with those of SENC/HARP with good limits of agreement. MTT could serve as a useful tool for clinical assessment of regional cardiac function.