Investigating a new drug delivery nano composite membrane system based on PVA/PCL and PVA/HA(PEG) for the controlled release of biopharmaceuticals for bone infections. (December 2015)

• Record Type: Journal Article
• Authors: Wan, Taoyu; Stylios, George K.; Giannoudi, Marilena; Giannoudis, Peter V.
• Is Part Of: Injury. Volume 46:Supplement 8(2015)
• Page Start: S39
• Page End: S43
• Publication Date: 2015-12
• Subjects: drug delivery -- poly(e-caprolactone) -- PVA hydrogels -- bone infections -- controlled delivery -- nano composite -- nano membrane; Wounds and injuries -- Surgery -- Periodicals; Accidents -- Periodicals; Wounds and Injuries -- surgery -- Periodicals; Lésions et blessures -- Chirurgie -- Périodiques; Electronic journals; Electronic journals; 617.1
• DOI: 10.1016/S0020-1383(15)30053-X
• Languages: English
• ISSNs: 0020-1383

Abstract

Abstract: The capability for sustained and gradual release of pharmaceuticals is a major requirement in the development of a guided antimicrobial bacterial control system for clinical applications. In this study, PVA gels with varying constituents that were manufactured via a refreeze/thawing route, were found to have excellent potential for antimicrobial delivery for bone infections. Cefuroxime Sodium with poly(ethylene glycol) was incorporated into 2 delivery systems poly(e-caprolactone) (PCL) and hydroxyapatite (HA), by a modified emulsion process. Our results indicate that the Cefuroxime Sodium released from poly(e-caprolactone) in PVA was tailored to a sustained release over more than 45 days, while the release from hydroxyapatite PVA reach burst maximum after 20 days. These PVA hydrogel-systems were also capable of controlled and sustained release of other biopharmaceuticals.