Heterogeneity of Muscle Blood Flow and Metabolism: Influence of Exercise, Aging, and Disease States. Issue 3 (July 2015)

• Record Type: Journal Article
• Authors: Heinonen, Ilkka; Koga, Shunsaku; Kalliokoski, Kari K.; Musch, Timothy I.; Poole, David C.
• Is Part Of: Exercise and sport sciences reviews. Volume 43:Issue 3(2015:Jul.)
• Publication Date: 2015-07
• Subjects: blood flow -- oxygen utilization -- heterogeneity -- muscle -- exercise -- aging -- diseases; Sports -- Physiological aspects -- Periodicals; Exercise -- Physiological aspects -- Periodicals; Sports medicine -- Periodicals; 612.76
• DOI: 10.1249/JES.0000000000000044
• Languages: English
• ISSNs: 0091-6331

Abstract

Abstract : The systematic increase in V˙O2 uptake and O2 extraction with increasing work rates conceals a substantial heterogeneity of O2 delivery (Q˙O2 )-to- V˙O2 matching across and within muscles and other organs. We hypothesize that whether increased/decreased Q˙O2 /V˙O2 heterogeneity can be judged as "good" or "bad, " for example, after exercise training or in aged individuals or with disease (heart failure, diabetes) depends on the resultant effects on O2 transport and contractile performance. Abstract : Muscle Q˙O2 /V˙O2 heterogeneity may be key to subserving different regional exercise O2 demands in health, but derangements in disease may be detrimental to blood-myocyte O2 flux and contractile performance in disease states.