Zwitterionic diketopyrrolopyrrole for fluorescence/photoacoustic imaging guided photodynamic/photothermal therapy. Issue 20 (25th April 2018)

• Record Type: Journal Article
• Authors: Deng, Weixing; Wu, Qi; Sun, Pengfei; Yuan, Pengcheng; Lu, Xiaomei; Fan, Quli; Huang, Wei
• Is Part Of: Polymer chemistry. Volume 9:Issue 20(2018)
• Page Start: 2805
• Page End: 2812
• Publication Date: 2018-04-25
• Subjects: Polymers -- Periodicals; Macromolecules -- Periodicals; Polymerization -- Periodicals; 547.705
• DOI: 10.1039/c8py00244d
• Languages: English
• ISSNs: 1759-9954

Abstract

Abstract : Water-soluble zwitterionic diketopyrrolopyrrole (DPP-SPMA) for fluorescence/photoacoustic imaging guided photodynamic/photothermal therapy with favorable renal excretion and ultralow cytotoxicity. Abstract : Dual-modal imaging and dual-modal therapy provide multiple complementary theranostic features. The theranostic agent has favorable renal excretion and low cytotoxicity, making it of great interest in the nanomedical field. Herein, a water-soluble conjugated zwitterionic polymer (DPP-SPMA) with low-fouling and low cytotoxicity was prepared and used for fluorescence/PA imaging guided PTT/PDT therapy. The in vivo imaging results showed that the DPP-SPMA had excellent enhanced permeability and retention effects. The fluorescence imaging demonstrated that the DPP-SPMA was excreted by renal metabolism because the controlled molecular mass was less than the renal filtration threshold. The DPP-SPMA shows a photothermal effect under 730 nm irradiation and an excellent singlet oxygen generation capacity for the PDT therapy under 635 nm irradiation. The high accumulation of DPP-SPMA by passive targeting around the tumor stimulated excellent synergistic photodynamic therapy and photothermal therapy. As a result, the water-soluble zwitterion DPP-SPMA was well suited for fluorescence/PA dual-modal imaging and had significant antitumor activity in vivo via synergistic photodynamic therapy and photothermal therapy.