Rotavirus and norovirus in children with severe diarrhea in Burkina Faso before rotavirus vaccine introduction. Issue 9 (25th May 2018)

• Record Type: Journal Article
• Authors: Bonkoungou, Isidore Juste O.; Ouédraogo, Nafissatou; Tamini, Laure; Teguera, Rabieta Kouboura; Yaméogo, Pouiré; Drabo, Maxime Koiné; Medah, Isaïe; Barro, Nicolas; Sharma, Sumit; Svensson, Lennart; Nordgren, Johan
• Is Part Of: Journal of medical virology. Volume 90:Issue 9(2018)
• Page Start: 1453
• Page End: 1460
• Publication Date: 2018-05-25
• Subjects: Burkina Faso -- gastroenteritis -- molecular epidemiology -- norovirus (NoV) -- rotavirus; Virology -- Periodicals; 616
• DOI: 10.1002/jmv.25213
• Languages: English
• ISSNs: 0146-6615

Abstract

Abstract : Burkina Faso introduced rotavirus vaccine (RotaTeq) to the national immunization program in November 2013. This study describes the detection rates, clinical profiles, and molecular epidemiology of rotavirus and norovirus (NoV) infections among children <5 years hospitalized (n = 154) because of acute diarrhea in Ouagadougou, Burkina Faso, from December 2012 to November 2013, just before the start of vaccination. Overall, 44% and 23% of fecal samples were positive for rotavirus and NoV, respectively, most of them detected during the cold dry season (December‐March). The predominant G/P combinations were G12P[8] (47%) and G6P[6] (30%). G2P[4] (n = 3), G12P[6] (n = 3), and G6P[8] (n = 1) were also detected. Nearly all (94%) successfully genotyped NoV strains belonged to genotype GII.4. The predominance of rotavirus and NoV was noteworthy in the age group ≤6 months, with 67% rotavirus and 22% NoV, respectively. Vomiting was significantly more common among rotavirus‐infected children. To conclude, this study shows high detection rates of both rotavirus and NoV in children with severe diarrhea in Burkina Faso just before the introduction of rotavirus group A vaccination. The results can be used for estimating the impact of rotavirus group A vaccination, which started in the end of 2013. Furthermore, this study shows that the G6P[6] rotavirus strains emerging in Burkina Faso in 2010 is now established as a regionally important genotype. Abstract : High detection rates of rotavirus and norovirus in children with severe diarrhea in Burkina Faso before rotavirus vaccine introduction. A predominance of the emerging rotavirus G12P[8] and the globally rare G6P[6] genotypes. Nearly all norovirus oberverd were of genotype GII.4. The G6P[6] rotavirus strains now seem established as regionallly important genotype