Combined effects of 3D bone marrow stem cell-seeded wet-electrospun poly lactic acid scaffolds on full-thickness skin wound healing. Issue 15 (13th October 2018)

• Record Type: Journal Article
• Authors: Ghorbani, Sadegh; Eyni, Hossein; Tiraihi, Taki; Salari Asl, Leila; Soleimani, Masoud; Atashi, Amir; Pour Beiranvand, Shahram; Ebrahimi Warkiani, Majid
• Is Part Of: International journal of polymeric materials. Volume 67:Issue 15(2018)
• Page Start: 905
• Page End: 912
• Publication Date: 2018-10-13
• Subjects: 3D nanofiber scaffold -- poly lactic acid scaffold -- skin tissue engineering -- wet electrospinning -- wound healing; Polymers -- Periodicals; Plastics -- Periodicals; 620.19205
• DOI: 10.1080/00914037.2017.1393681
• Languages: English
• ISSNs: 0091-4037

Abstract

ABSTRACT: Tissue engineering has emerged as an alternative treatment to traditional grafts for skin wound healing. Three-dimensional nanofibers have been used extensively for this purpose due to their excellent biomedical-related properties. In this study, high porous 3D poly lactic acid nanofibrous scaffolds (PLA-S) were prepared by wet-electrospinning technique and seeded with rat bone-marrow stem cells (BMSCs) to characterize the biocompatibility and therapeutic efficacy of these fibers on the treating full-thickness dermal wounds. The results of in vitro and in vivo studies indicate that the 3D fibrous PLA-S can be a potential wound dressing for wound repair, particularly when seeded with BMSCs. GRAPHICAL ABSTRACT: