Biology of Cancer; From Cellular Cancerogenesis to Supracellular Evolution of Malignant Phenotype. (28th May 2018)

• Record Type: Journal Article
• Authors: Motofei, Ion G.
• Is Part Of: Cancer investigation. Volume 36:Number 5(2018)
• Page Start: 309
• Page End: 317
• Publication Date: 2018-05-28
• Subjects: Cellular cancerogenesis -- Supracellular malignant phenotype -- Cancer biology -- Tumor immunology -- Autoimmunity; Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.1080/07357907.2018.1477955
• Languages: English
• ISSNs: 0735-7907

Abstract

Abstract: Until now cancerogenesis has been studied in close relation with the corresponding malignant phenotype. Such unified approach defines cancer as uncontrolled cellular multiplication, associating invasion and metastasis. Contrary to the classical approach, this paper presents cancerous disease from two distinct perspectives: cancerogenesis as the cause (investigated especially to cellular or molecular level), and malignant phenotype as the resulting effect (with supracellular evolution). It is advanced the perspective that exacerbated cell division in cancer would be actually a very responsive event to supracellular signals, which are received from extracellular matrix and supracellular programs of the body.