Prolonged drug release using PCL–TMZ nanofibers induce the apoptotic behavior of U87 glioma cells. Issue 15 (13th October 2018)

• Record Type: Journal Article
• Authors: Tavakoli, Rezvan; Vakilian, Saeid; Jamshidi-Adegani, Fatemeh; Sharif, Samaneh; Ardeshirylajimi, Abdolreza; Soleimani, Masoud
• Is Part Of: International journal of polymeric materials. Volume 67:Issue 15(2018)
• Page Start: 873
• Page End: 878
• Publication Date: 2018-10-13
• Subjects: Controlled release -- glioma -- polycaprolactone -- temozolomide; Polymers -- Periodicals; Plastics -- Periodicals; 620.19205
• DOI: 10.1080/00914037.2017.1393677
• Languages: English
• ISSNs: 0091-4037

Abstract

ABSTRACT: In situ prolonged delivery of drugs at the site of tumor can be satisfactorily accelerated patient recovery. We compared the effect of temozolomide while incorporated by polycaprolactone nanofibers on the apoptotic behavior of U87 glioma cells. After biocompatibility evaluation of nanofibers by scanning electron microscope and 3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide analysis, the apoptosis of U87 cells was evaluated using p53, Bcl2 and Bax genes expression. It was found that nanofiber-temozolomide group showed a greater ability to induce apoptosis as well as have a significantly diminished initial burst release of drug compared with other groups and have promising potential in treating cancer. GRAPHICAL ABSTRACT: