Dose to Pelvic Bone Marrow Defined with FDG-PET Predicts for Hematologic Nadirs in Anal Cancer Patients Treated with Concurrent Chemo-radiation. (28th May 2018)

• Record Type: Journal Article
• Authors: Franco, Pierfrancesco; Arcadipane, Francesca; Ragona, Riccardo; Lesca, Adriana; Gallio, Elena; Mistrangelo, Massimiliano; Trino, Elisabetta; Cassoni, Paola; Arena, Vincenzo; Baccega, Massimo; Racca, Patrizia; Faletti, Riccardo; Rondi, Nadia; Morino, Mario; Ricardi, Umberto
• Is Part Of: Cancer investigation. Volume 36:Number 5(2018)
• Page Start: 279
• Page End: 288
• Publication Date: 2018-05-28
• Subjects: Anal cancer -- IMRT -- PET -- Hematologic toxicity -- Concomitant radiochemotherapy -- Radiotherapy -- Bone marrow; Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.1080/07357907.2018.1479413
• Languages: English
• ISSNs: 0735-7907

Abstract

Abstract: Purpose: To investigate whether irradiated volume of pelvic active bone marrow ( ACT BM) may predict decreased blood cells nadirs in anal cancer patients undergoing concurrent chemo-radiation. Methods: Forty-four patients were analyzed and pelvic active bone marrow ( ACT BM) was characterized employing 18 FDG-PET. Dosimetric parameters on dose–volume histograms were correlated to nadirs with generalized linear modeling. Results: ACT BM mean dose was significantly correlated to white blood cell ( β = −1.338; 95%CI: −2.455/−0.221; p = 0.020), absolute neutrophil count ( β = −1.651; 95%CI: −3.284/−0.183; p = 0.048), and platelets ( β = −0.031; 95%CI: −0.057/−0.004; p = 0.024) nadirs. Other dosimetric parameters were found to be correlated ( ACT BM-V10, -V20, -V30 and-V40 ). Conclusions: 18 FDG-PET is able to define active bone marrow and may predict for decreased blood cells count nadirs.