A supramolecular hybrid material constructed from pillar[6]arene-based host–guest complexation and ZIF-8 for targeted drug delivery. Issue 70 (15th August 2018)

• Record Type: Journal Article
• Authors: Yang, Kui; Yang, Ke; Chao, Shuang; Wen, Jia; Pei, Yuxin; Pei, Zhichao
• Is Part Of: Chemical communications. Volume 54:Issue 70(2018)
• Page Start: 9817
• Page End: 9820
• Publication Date: 2018-08-15
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c8cc05665j
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A well dispersive supramolecular hybrid material ZIF-8@DOX@WP6@G constructed from the host–guest complexation between carboxylated pillar[6]arene (WP6) and a galactose derivative (G), and doxorubicin (DOX)-loaded ZIF-8 has been synthesized for targeted drug delivery. Abstract : A novel supramolecular hybrid material ZIF-8@DOX@WP6@G constructed from the host–guest complexation between carboxylated pillar[6]arene (WP6) and a galactose derivative (G), and doxorubicin (DOX)-loaded ZIF-8 has been synthesized for targeted drug delivery. The results showed that ZIF-8@DOX@WP6@G not only maintained the pH-sensitive drug release properties of ZIF-8 but also exhibited excellent water dispersibility and selective toxicity for hepatoma cancer cells due to the assembly of WP6 and G. The strategy used in this study opens up a new avenue for constructing multifunctional supramolecular hybrid materials for therapeutic applications in cancer treatment.