Aberrant Expression of Osteopontin and E-Cadherin Indicates Radiation Resistance and Poor Prognosis for Patients with Cervical Carcinoma. (February 2015)

• Record Type: Journal Article
• Authors: Huang, Xinqiong; Qian, Yujie; Wu, Hainan; Xie, Xiaoxue; Zhou, Qin; Wang, Ying; Kuang, Weilu; Shen, Lin; Li, Kai; Su, Juan; Shen, Liangfang; Chen, Xiang
• Is Part Of: Journal of histochemistry and cytochemistry. Volume 63:Number 2(2015:Feb.)
• Page Start: 88
• Page End: 98
• Publication Date: 2015-02
• Subjects: locally advanced cervical squamous cell carcinoma -- radiation resistance -- osteopontin -- E-cadherin -- epithelial-mesenchymal transition -- immunohistochemistry; Histochemistry -- Periodicals; Cytochemistry -- Periodicals; Histocytochemistry -- methods; Histological Techniques; 572.05
• DOI: 10.1369/0022155414561329
• Languages: English
• ISSNs: 0022-1554

Abstract

Radiotherapy is the first-line treatment for all stages of cervical cancer, whether it is used for radical or palliative therapy. However, radioresistance of cervical cancer remains a major therapeutic problem. Consequently, we explored if E-cadherin (a marker of epithelial-mesenchymal transition) and osteopontin could predict radioresistance in patients with locally advanced cervical squamous cell carcinoma (LACSCC). Patients were retrospectively reviewed and 111 patients divided into two groups (radiation-resistant and radiation-sensitive groups) according to progression-free survival (PFS). In pretreated paraffin-embedded tissues, we evaluated E-cadherin and osteopontin expression using immunohistochemical staining. The percentage of patients with high osteopontin but low E-cadherin expression in the radiation-resistant group was significantly higher than those in the radiation-sensitive group ( p <0.001). These patients also had a lower 5-year PFS rate ( p <0.001). Our research suggests that high osteopontin but low E-cadherin expression can be considered as a negative, independent prognostic factor in patients with LACSCC ([Hazard ratios (95% CI) 6.766 (2.940, 15.572)], p <0.001).