PP.11.20: PREVALENCE OF HYPERTENSION AND POORLY CONTROLLED HYPERTENSION 6 AND 12 MONTH AFTER SOLID ORGAN TRANSPLANTATION IN THE SWISS TRANSPLANT COHORT STUDY. (June 2015) - Lu, Y.
Abstract : Objective: Prevalence of hypertension (HTN) is high after solid organ transplantation (SOT) and has been associated to graft failure, death-censored graft failure and death. The Swiss Transplant Cohort Study has enrolled SOT participants prospectively since 2008. No data on the prevalence of HTN and poorly controlled HTN has been reported from this cohort so far. The objective was therefore to determine the prevalence of HTN and poorly controlled HRN Design and method: Patients' characteristics including Blood pressure (BP) data were recorded at 6 and 12 months. HTN was defined as BP > 140/90 mmHg or the use of antihypertensive drugs. Uncontrolled HTN was defined as BP > 140/90 mmHg despite the use of antihypertensive drugs. Data from 1236 participants were available at baseline (time of SOT). Results: 64.8% of the participants were male, mean age was 52.0 ± 13.1 years (mean ± standard deviation), mean body mass index was 25.0 ± 13, 1 Kg/m2. Table 1.Prevalence of HTN and poorly controlled HTN 6 and 12 month after SOT. Figure. No caption available. At 6 and 12 months, the prevalence of HTN was different among the different organs (p < 0.001). The prevalence of uncontrolled HTN among the different organs was different at 6 months (p = 0.013) but not at 12 months (p = 0.080). In multivariate analysis age was associated with an increased risk of uncontrolled HTN at 6 and 12 months. Sex (male) and the number of antihypertensive drug used were associated with HTN at 6 months. Conclusions: The prevalence of HTN after SOT is high but dependent of the organ transplanted. Despite the use of antihypertensive drugs in most SOT patients, uncontrolled HTN is frequent, particularly in kidney transplants.