PP.04.20: LEFT VENTRICULAR HYPERTROPHY AT THE VERY BEGINNING OF HYPERTENSION. (June 2015)

• Record Type: Journal Article
• Authors: Chatzistamatiou, E.; Vagena, I. Babatseva; Konstantinidis, D.; Memo, G.; Moustakas, G.; Markou, M.; Paggratis, V.; Avgeropoulou, A.; Tousoulis, D.; Kallikazaros, I.
• Is Part Of: Journal of hypertension. Volume 33(2015)Supplement 1
• Publication Date: 2015-06
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000467836.93331.05
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Objective: Development of left ventricular hypertrophy (LVH) is a multifactorial and incompletely understood process. Aim of our study was to determine the contributory factors for this maladaptive phenomenon, at the very beginning of essential hypertension. Design and method: We studied 780 consecutive newly diagnosed, never treated, non-diabetic, hypertensive patients stage I-III (51 ± 13 years old, 45.3% females). Echocardiographic left ventricular mass calculation was performed from parasternal long axis and normalized for height in meters to the power of 2.7 (LVMi). Using established cutoffs (>49 for males and >45 g/m2.7 for females), the study population was split in group with normal (n = 649) and increased LVMi (n = 131). Results: Prevalence of normal geometry and concentric remodeling in patients with normal LVMi was 53% and 47%, while prevalence of concentric and eccentric hypertrophy in patients with LVH was 71.4% and 28.6%, respectively. LVMi was significantly correlated with age, BMI, waist and hip circumference, metabolic syndrome, snoring, hs-CRP, HbA1c, GFRCKD-EPI, uric acid, triglycerides and HDL-cholesterol, aortic pulse wave velocity, microalbuminuria, left atrial volume index, diastolic dysfunction grade, carotid IMT and plaques, severity of hypertension, number of CV risk factors and TODs. Patients with LVH were older, with higher general and abdominal obesity, impaired metabolic, hemodynamic and TODs profile (Table). Figure. No caption available. Conclusions: In newly diagnosed hypertensive patients left ventricular hypertrophy is already present in a sizable proportion being the result not only of BP levels but also of numerous metabolic and CVD risk factors.