PP.06.30: REVALENCE OF EARLY VASCULAR AGEING ACCORDING TO VASERA EXAMINATION IN RUSSIAN POPULATION. (June 2015)

• Record Type: Journal Article
• Authors: Soldatenkova, N.; Rotar, O.; Orlov, A.; Boyarinova, M.; Alieva, A.; Vasilieva, E.; Baranova, E.; Rogoza, A.; Konradi, A.O.
• Is Part Of: Journal of hypertension. Volume 33(2015)Supplement 1
• Publication Date: 2015-06
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000467904.11707.e0
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Objective: Vascular age is the apparent age of the arteries that can be affected by genetic predisposition, lifestyle and other factors. Subjects whose vascular age is higher than chronological age may have higher cardiovascular risk. The aim of our study was estimate prevalence and risk factors of early vascular aging (EVA) in Russian population according to VaSera examination results. Design and method: 1600 apparently healthy participants aged 25-65 years were randomly selected from Saint-Petersburg inhabitants (sample from ESSE-RF study). Data of 1361 subjects were available for analysis. Fasting lipids, glucose (Abbott Architect 8000 (USA)) and blood pressure (BP) measurement by Omron (Japan) were performed. Cardio-ankle vascular index (CAVI) was detected by VaSera VS-1500 (Fukuda, Japan). We presumed new definition of EVA - vascular age calculated from pressure independent stiffness index (CAVI) exceeded the biological age >4 years. EVA was revealed in 289 participants (21, 2%). Elevated BP was considered as BP > 140/90 mm Hg or antihypertensive treatment; increased total cholesterol (TC) > 4.9 mmol/l: low-density lipoproteins (LDL)>3.0 mmol/l; triglycerides (TG) >1.7 mmol/l, high density lipoproteins (HDL) <1, 0 (M) and 1, 3 (F) mmol/l. Multiple regression analysis was applied (SSPS Statistics 20) Results: Subjects with increased vascular age had significantly higher biological age comparing with other participants (52, 1 ± 10, 4 vs 45, 8 ± 11, 8 years, p < 0.001). The main determinants of increased vascular age are presented in the table. Table 1. Risk factors of increased vascular age in general population Figure. No caption available. Conclusions: Chronological aging facilitates accumulation of risk factors that lead to advanced vascular aging. Hypertension has the greatest contribution to the early vascular aging, hyperlipidemia and diabetes are less important.