Risk of metabolic syndrome in adolescents with polycystic ovarian syndrome: A systematic review and meta-analysis. Issue 6 (November 2018)

• Record Type: Journal Article
• Authors: Fazleen, Nur Ezza; Whittaker, Maxine; Mamun, Abdullah
• Is Part Of: Diabetes & metabolic syndrome. Volume 12:Issue 6(2018)
• Page Start: 1083
• Page End: 1090
• Publication Date: 2018-11
• Subjects: ASRM American Society for Reproductive Medicine -- BMI body metabolic index -- BP blood pressure -- CINAHL cumulative index to nursing and allied health literature -- DBP diastolic blood pressure -- EMBASE excerpta medical database -- ESHRE European Society of Human Reproduction and Embryology -- FBG fasting blood glucose -- HDL high density lipid -- IDF International Diabetes Federation -- LDL low density lipid -- MeSh medical subject heading -- MetS metabolic syndrome -- NCEP ATP III national cholesterol education program expert panel on detection, evaluation and treatment of high blood cholesterol in adults -- NIH National Institute of Health -- PCOS polycystic ovarian syndrome -- PRISMA preferred reporting items for systematic reviews and meta-analyses -- SBP systolic blood pressure -- TG triglycerides -- VS versus -- WC waist circumference; Polycystic ovarian syndrome -- Metabolic syndrome -- Adolescents; Diabetes -- Periodicals; Metabolism -- Disorders -- Periodicals; Diabetes Mellitus -- Periodicals; Metabolic Diseases -- Periodicals; Diabète -- Périodiques; Métabolisme, Troubles du -- Périodiques; Endocrinologie -- Périodiques; Diabète -- Physiopathologie -- Périodiques; Diabetes; Metabolism -- Disorders; Electronic journals; Periodicals; 616.462
• DOI: 10.1016/j.dsx.2018.03.014
• Languages: English
• ISSNs: 1871-4021

Abstract

Abstract: Background: Polycystic ovarian syndrome (PCOS) is the commonest reproductive disorder in women and is closely associated with the development of metabolic syndrome (MetS). The objective of this systematic review and meta-analysis was to describe the risk of MetS in adolescent with PCOS to help diagnosing and preventing of morbidity and mortality later in life. Methods: Pubmed, Medline, EMBASE, CINAHL and other sources were searched for metabolic syndrome in adolescents with polycystic ovarian syndrome using PRISMA guidelines (Moher et al., 2009). All type of study design of women aged 10–20 reported association of PCOS with metabolic syndrome was included in this study. Meta-analysis was conducted for MetS and its individual component using bias adjusted quality effect model and we compare the results from quality effects with random effects and IVhet model. Data were presented as prevalence, odds ratio (95% confidence interval and mean difference (95% confidence interval). Results: This systematic review included 9 studies while the meta-analysis included 7 studies. Meta-analysis showed that the odds of being experiencing MetS in PCOS groups was 2.69 (1.29, 5.60) times than girls without PCOS. The mean difference between girls with PCOS and without PCOS for systolic blood pressure was 5.00 (1.28, 8.72), diastolic blood pressure was 3.50 (0.48, 6.56), triglycerides level was 4.20 (−3.99, 12.45), glucose level was 1.30 (−0.46, 3.05), HDL level was −1.40 (−4.85, 2.00). Conclusion: This systematic review and meta-analysis support the hypothesis that the risk of MetS is much greater in adolescents with PCOS compared to the normal population. It is important to screen PCOS in early age to prevent MetS and its complications which lead to morbidity and mortality later in life.