Current mouse models of oral squamous cell carcinoma: Genetic and chemically induced models. (October 2017)

• Record Type: Journal Article
• Authors: Ishida, Kazuhisa; Tomita, Hiroyuki; Nakashima, Takayuki; Hirata, Akihiro; Tanaka, Takauji; Shibata, Toshiyuki; Hara, Akira
• Is Part Of: Oral oncology. Volume 73(2017)
• Page Start: 16
• Page End: 20
• Publication Date: 2017-10
• Subjects: Mouse model -- Genetically modified mouse -- Oral cavity -- Squamous cell carcinoma; Mouth -- Cancer -- Periodicals; Mouth -- Tumors -- Periodicals; Mouth Diseases -- Periodicals; Mouth Neoplasms -- Periodicals; Bouche -- Cancer -- Périodiques; Bouche -- Tumeurs -- Périodiques; Tumeurs -- Périodiques; Electronic journals; 616.9943105
• DOI: 10.1016/j.oraloncology.2017.07.028
• Languages: English
• ISSNs: 1368-8375

Abstract

Highlights: There is a few suitable mouse models in oral squamous cell carcinoma (OSCC). The 4NQO-induced mouse model phenocopies the human OSCC. Genetically engineered mouse models can clarify the molecular pathogenesis of OSCC. Abstract: Oral squamous cell carcinoma (OSCC) patients have a low 5-year survival rate and poor prognosis. To improve survival and prognosis, the causes and processes involved in lesion development should be evaluated. For this purpose, the use of OSCC mouse models, such as chemically induced mouse models, genetically modified mouse models, and transplanted (xenograft) models, is crucial. These OSCC models exhibit both advantages and disadvantages when studying OSCC development and progression. Until a model resembling human OSCC is developed, both the advantages and disadvantages of each model should be carefully considered. In this review, we discuss OSCC mouse models and their use in cancer research worldwide.