Stimulators of acylated ghrelin secretion from Moringa oleifera leaves. (September 2017)

• Record Type: Journal Article
• Authors: Ohta, Tomoe; Nakamura, Seikou; Nakashima, Souichi; Shimakawa, Hiroyuki; Emi, Yuika; Matsumoto, Takahiro; Ogawa, Keiko; Fukaya, Masashi; Oda, Yoshimi; Matsuda, Hisashi
• Is Part Of: Phytochemistry letters. Volume 21(2017:Sep.)
• Page Start: 1
• Page End: 5
• Publication Date: 2017-09
• Subjects: Moringa oleifera -- Moringaside A -- Moringamegastigmane A -- Acylated ghrelin; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2017.04.022
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: A new nitrogen-containing phenolic glycoside, moringaside A, was isolated from the leaves of Moringa oleifera . A new megastigmane glycoside, moringamegastigmane A, was isolated from the leaves of M. oleifera. Their chemical structures of new constituents were elucidated. Among the compounds from M. oleifera, niazirin significantly stimulated acylated ghrelin secretion in vitro . Abstract: A new nitrogen-containing phenolic glycoside, moringaside A (1 ), and a new megastigmane glycoside, moringamegastigmane A (2 ), were isolated from the leaves of Moringa oleifera together with 16 known compounds. The chemical structures of the isolated compounds were elucidated on the basis of chemical and physicochemical evidence. To the best of our knowledge, there are few reports of compounds that effect acylated ghrelin secretion. Among the constituents of M. oleifera, niazirin (5 ) significantly stimulated the secretion of acylated ghrelin in vitro using rat primary gastric cells. This result suggests that5 is a promising therapeutic agent for anorexia.