7B.08: HIGH BLOOD PRESSURE AND ITS VARIATION AND THE USE OF BETA BLOCKING AGENTS AND STATINS DECREASE QUALITY OF LIFE IN DRUG-TREATED HYPERTENSIVE PATIENTS. (June 2015)

• Record Type: Journal Article
• Authors: Kantola, I.; Merikari, M.; Tervo, J.; Koskio, L.; Haijanen, J.; Hermansson, H.; Kantola, T.; Mäkelä, P.; Rehunen, S.; Varis, J.
• Is Part Of: Journal of hypertension. Volume 33(2015)Supplement 1
• Publication Date: 2015-06
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000467605.15859.cf
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Objective: To clarify explanatory factors to quality of life in Finnish drug-treated hypertensive patients. Design and method: SF-36 questionnaire was filled out by 174 hypertensive patients (66 females, 108 males, aged 64.5(8.5)years). All used at least one antihypertensive agent. 24 hour ambulatory blood pressure(ABPM) and pulse wave- velocity(PWV) were performed and laboratory tests taken. Results: 24-hour ambulatory SBP was 132.1(12.6)mmHg and DBP 76.6(7.2) mmHg and LDL-cholesterol 2.6(0.7) mmol/l. Carotid-femoral-PWV was 11.3(3.7)m/s. The mean(SD) of the eight SF-36 questionnaire scores was 74.1(18.4) (maximum 100). All scores correlated significantly(p < 0.001)to each other. The use of beta-blockers correlated negatively to most of the quality of life parameters and the use of statins negatively to role-physical, general health and vitality. According to the regression model physical functioning was explained by lower ABPM nighttime pulse pressure(PP), daytime DBP standard deviation(SD) and home measured evening PP(model explained 83.6 % of the variation). Role-physical by not using either acetosalicylic acid or clopidogrel (25.5%). Bodily pain rate by lower ABPM daytime mean arterial pressure SD and higher SBP SD and 24 hour heart rate SD, lower age and not using diuretics(64.2%). General health by lower GHbA1c, not using beta-blockers and lower ABPM nighttime PP SD(22.6%). High vitality by lower carotid radial PWV and ABPM daytime DBP SD(41.3%). Social functioning by lower carotid radial PWV and not using ASA or clopidogrel (65.2%). High role-emotional by not using beta blockers or ASA or clopidogrel (54.4%). Mental health by lower carotid radial PWV(56.4%), Reported health transition by higher ABPM nighttime PP SD and the use of ASA or clopidogrel (14.6%). The mean of all the eight SF-36 questionnaire scores by lower home measured evening SBP and not using ASA or clopidogrel (61.2%). Conclusions: The SF-36 scores of the Finnish drug-treated hypertensive patients did not differ markedly from the same age American healthy population and hypertensive patients used in validation of questionnaire. High BP and its variation seemed to decrease quality of life. Also control of other cardiovascular risk factors seemed to be important. The use of beta- blocking agents and statins seemed to decrease quality of life.