7D.12: TELMISARTAN MONOTHERAPY EFFECTS ON MICROCIRCULATION IN PATIENTS WITH UNCOMPLICATED ARTERIAL HYPERTENSION. (June 2015)

• Record Type: Journal Article
• Authors: Dogotar, O.; Sopetik, V.; Kotovskaya, Y.
• Is Part Of: Journal of hypertension. Volume 33(2015)Supplement 1
• Publication Date: 2015-06
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000467629.01505.b1
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Objective: To evaluate telmisartan monotherapy effects on structural and functional characteristics of small-caliber vessels in patients with uncomplicated arterial hypertension (AH). Design and method: 20 patients (age 50, 2 ± 12, 8 years; male - 65%) with untreated uncomplicated grade I-II AH are included into the study. All patients were treated by telmisartan 80 mg during 8 weeks. At baseline and after 8 weeks the parameters of microcirculation were measured. The parameters of microcirculation were evaluated by laser Doppler flowmetry: index of microcirculation (IM, perf.units), which characterizes basal blood flow; occlusion test - capillary blood flow reserve (CBFR), which characterizes the reversibility of remodeling microvasculature; difference index of microcirculation (DIM), which indicates the degree of reduction in blood flow during occlusion; half-recovery time of capillary blood flow (T1/2, s), which characterizes the reactivity of the vascular bed; index of increase in capillary blood flow (IICBF, perf.units), which indicates an increase in vasoconstriction. Data presented as M ± m. Wilcoxon criteria for by-pair comparisons was used. p < 0, 05 was considered significant. Results: After 8 weeks of treatment BP decreased from 154, 4 ± 2, 5/98, 4 ± 1, 8 mmHg to 136, 2 ± 3, 1/84, 9 ± 2, 5 mmHg (p = 0, 0077). 55% of surveyed have reached target BP levels < 140/90 mmHg. 25% responded to treatment determined as decrease in systolic BP >20 mmHg or diastolic BP>10 mmHg. Significant increase (p < 0, 05) of IM from 2, 93 ± 0, 39 perf.units to 4, 22 ± 0, 75 perf.units was observed. CBFR decreased from 391, 1 ± 25, 5% to 295, 4 ± 29, 2% (p < 0, 05). According to the occlusion test were observed recovery of normal type reactions to arterial occlusion: DIM increased from 1, 63 ± 0, 30 perf.units to 2, 27 ± 0, 68 perf.units (p < 0, 05). IICBF and T1/2 were not significantly changed. Conclusions: Telmisartan monotherapy (dose – 80 mg), 8-weeks course, contributes to restore normal hemodynamic type of microcirculation, normalizes microcirculation response to arterial occlusion and improves capillary blood flow reserve.