4B.09: DIABETES MELLITUS AND ORGAN DAMAGE, CARDIOVASCULAR DISEASE AND MORTALITY IN HYPERTENSIVE PATIENTS. (June 2015)

• Record Type: Journal Article
• Authors: Tasic, I.; Kostic, S.; Djordjevic, D.; Lovic, D.; Lovic, M.; Miladinovic-Tasic, N.
• Is Part Of: Journal of hypertension. Volume 33(2015)Supplement 1
• Publication Date: 2015-06
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000467493.99352.55
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Objective: Diabetes mellitus is an important contributor to a vascular damage inducing a high risk of macro-and microvascular complications. In this study, we tried to evaluate the proposed correlation of diabetes with target organ damage and cardiovascular disease and mortality in hypertensive patients. Design and method: We studied 134 participants (91 females, 43 males). Each participant underwent asymptomatic organ damage: 12-lead electrocardiogram examination, two-dimensional and Doppler echocardiography, colour Doppler sonography of the carotid arteries, laboratory investigations were prospectively followed for total and cardiovascular mortality and disease over a median of 6 years. Results: They had a mean age of 62.9 ± 8.5 years, body mass index of 28.9 ± 3.68 kg/m 2, office blood pressure of 158 ± 16.7/91 ± 10.8 mmHg, index left ventricular mass (LVM) of 139.1 ± 3.99 g/m2, carotid intima-medial thickness (IMT) of 0.94 ± 0.25 mm and presence of a plaque in 69 (51.5%) participants. Diabetes mellitus was found in 41 (30.6%) participants (group I). The mean value of blood pressure (144 vs. 145.9 mmHg), visit-to-visit blood pressure variability (16.8 vs. 16.9 mmHg), serum total cholesterol (5.25 vs. 5.4 mmol/l), and fasting serum triglycerides (1.83 vs. 1.77 mmol/l) did not differ between the groups in the end of the study. In group I, 27(66%) participants presence of a plaques in carotids, vs. 43(46%) participants in group II (p < 0.04). Mean Carotid IMT of 1.01 ± 0.22 in group I, vs. 0.91 ± 0.26 mm in group II (p < 0.04). Echocardiographic mean LVM index of 140.4 ± 30.1 in group I and 138.5 ± 31.66 g/m2 in group II (ns). A total of 5 (3.7%) participants died from cardiovascular disease, 4 patients from group I and 1 patients from group II (p < 0.02). Major CV events were observed in 13 participants (31.7%) from group I, while there were 13 (14%)(group II) (p < 0.02). In group I, 6 (14.6%) participants developed a malignant disease vs. 9(9.7%) participant in group II (ns). Conclusions: Diabetes mellitus in hypertensive patients is associated with higher incidences of asymptomatic carotid disease and major cardiovascular events.