5A.05: INCREASED ARTERIAL STIFFNESS IS AN INDEPENDENT PREDICTOR OF FUTURE ATRIAL FIBRILLATION IN HYPERTENSIVE PATIENTS. (June 2015)

• Record Type: Journal Article
• Authors: Gosse, P.; Cremer, A.; Laine, M.; Papaioannou, G.; Yeim, S.
• Is Part Of: Journal of hypertension. Volume 33(2015)Supplement 1
• Publication Date: 2015-06
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000467521.44133.7a
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Objective: Atrial fibrillation (AF) is certainly the most common arrhythmia and confers a high risk of stroke and cardiac failure. Hypertension and ageing are two important risk factors of incident AF and are both associated with increased arterial stiffness (AS). The possible relationship between AS and AF are insufficiently documented and probably complex. We tested these relations in hypertensive patients. Design and method: The patients included in this study belong to the Bordeaux cohort of hypertensive, a registry started in 1984 in which are included patients referred to our centre before administration of antihypertensive treatment and fulfilling the following criteria: Office BP > 140/90 on at least 2 occasions, Essential hypertension, no cardiovascular events or pathology likely to affect the prognosis, no type 1 diabetes. no history of AF, 24 h ambulatory measurement of BP coupled with the measurement of QKD interval inversely linked to AS (QKD100–60 (value for a systolic BP 100 mmHg and heart rate 60 bpm, corrected for patient's height and QRS duration and expressed as % of normal value = QKDh). An echocardiography was also performed at baseline in the majority of patients. AF free survival was analyzed according to the Cox model including sex, diabetes, smoking, hypercholesterolemia, QKDh, average 24 h PP and mean BP, mean 24 h HR, body mass index and left ventricular mass index (LVMI) and Left atrial Diameter (LAD) when available. Results: 853 have been recruited 67 new on-set of AF have been noticed with a mean follow up of 102 ± 62 months. Cox analysis found 3 variables significantly and independently linked to the occurrence of AF: age, QKDh and 24 h average HR Results remained unchanged when LVMI was introduced. When LAD was introduced (n = 480, 35 incident AF), 3 variables were significantly and independently linked to the occurrence of AF: age, QKDh and LAD. Figure. No caption available. HaRa: Hazard ratio, CI: 95% confidence interval Conclusions: Arterial stiffness is a strong predictor of future AF in hypertensive patients, independently of age, 24 h pulse pressure, LVMI and LAD.