Plant GSTome: structure and functional role in xenome network and plant stress response. (April 2015)

• Record Type: Journal Article
• Authors: Labrou, Nikolaos E; Papageorgiou, Anastassios C; Pavli, Ourania; Flemetakis, Emmanouil
• Is Part Of: Current opinion in biotechnology. Volume 32(2015)
• Page Start: 186
• Page End: 194
• Publication Date: 2015-04
• Subjects: Biotechnology -- Periodicals; 660.6
• DOI: 10.1016/j.copbio.2014.12.024
• Languages: English
• ISSNs: 0958-1669

Abstract

Graphical abstract: Highlights: GSTome contributes to cell detoxification, metabolism, stress/signalling. GSTome is organized in evolutionary distinct supergene families and classes. The structural flexibility contributes to functional and catalytic promiscuity. Abstract : Glutathione transferases (GSTs) represent a major group of detoxification enzymes. All plants possess multiple cytosolic GSTs, each of which displays distinct catalytic as well as non-catalytic binding properties. The progress made in recent years in the fields of genomics, proteomics and protein crystallography of GSTs, coupled with studies on their molecular evolution, diversity and substrate specificity has provided new insights into the function of these enzymes. In plants, GSTs appear to be implicated in an array of different functions, including detoxification of xenobiotics and endobiotics, primary and secondary metabolism, stress tolerance, and cell signalling. This review focuses on plant GSTome and attempts to give an overview of its catalytic and functional role in xenome and plant stress regulatory networks.