PP.02.17: CLINICAL SIGNIFICANCE OF SERUM NORADRENALINE IN ESSENTIAL HYPERTENSION. (June 2015)

• Record Type: Journal Article
• Authors: Seki, S.; Taniguchi, I.; Yoshimura, M.
• Is Part Of: Journal of hypertension. Volume 33(2015)Supplement 1
• Publication Date: 2015-06
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000467757.79938.3c
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Objective: Higher serum noradrenaline (NA) levels have been reported to be associated with higher prevalence of future cardiac event. We examined the association between NA level and clinical profile. Design and method: The NA levels and clinical parameters were retrospectively studied in 181 newly-diagnosed hypertensive patients (mean age 59.8 ± 11.1 years) without cardiovascular disease. The patients were divided into 2 groups based on median NA (300 pg/mL for men, 360 for women). Results: High NA patients (mean 481.7 pg/mL) showed higher heart rate (76.5 ± 13.8 vs. 70.5 ± 11.5 bpm, p < 0.001), renin activity (1.39 ± 1.28 vs. 0.86 ± 1.16 ng/mL/h, p < 0.01), peripheral white blood cell count (6050 ± 1600 vs. 5600 ± 1280 /mm 3, p < 0.05) and higher tendency of systolic blood pressure (168.6 ± 15.0 vs. 164.3 ± 15.0 mmHg, p = 0.056) compared with low NA patients (mean 236.9). The prevalence of metabolic syndrome was 40.0% in high NA and 24.2% in low NA patients (p < 0.05). No significant differences were found in age, body mass index and creatinine between the groups. In all patients, NA was significantly correlated with heart rate (r = 0.326/p < 0.001), renin activity (r = 0.263/p < 0.001) and high-sensitivity C-reactive protein (r = 0.275/p < 0.05). Conclusions: Results suggest that high NA levels may be associated with neurohumoral abnormality, inflammation and be useful to identify the high-risk patients in hypertension.