Phenylpropanoid amides from Alisma orientalis and their protective effects against H2O2-induced damage in SH-SY5Y cells. (September 2017)

• Record Type: Journal Article
• Authors: Xin, Xiu-Lan; Yu, Zhen-Long; Tian, Xiang-Ge; Wei, Jiang-Chun; Wang, Chao; Huo, Xiao-Kui; Ning, Jing; Feng, Lei; Sun, Cheng-Peng; Deng, Sa; Zhang, Bao-Jing; Zhang, Hou-Li; Zhao, Xin-Yu; Fan, Guang-Jun
• Is Part Of: Phytochemistry letters. Volume 21(2017:Sep.)
• Page Start: 46
• Page End: 50
• Publication Date: 2017-09
• Subjects: Alisma orientalis -- Alkaloid -- Phenylpropanoid amide -- Protective activity; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2017.05.027
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: Five new phenylpropanoid amides1–5 were isolated from rhizomes of A. orientalis . Compounds1– 9 were assayed for their protective effects. Compound5 displayed significant neuroprotective activity in SH-SY5Y cells. Abstract: Five new phenylpropanoid amides, including N - trans -feruloyl- N ′- cis -feruloyl-cadaverine (1 ), N, N′ - trans -diferuloyl-3-oxo-cadaverine (2 ), N - trans -feruloyl- N′ - cis -feruloyl-3-hydroxy-cadaverine (3 ), N, N′ - cis -diferuloyl-3-hydroxy-cadaverine (4 ), N - trans - p -coumaroyl- N′ - trans -feruloyl-3-hydroxy-cadaverine (5 ), were isolated from Alisma orientalis together with four known analogues. Their structural elucidations were conducted by using 1D and 2D NMR and HRESIMS spectroscopic analyses. The isolated compounds were assayed for their inhibitory activities against HCE-2, anti-oxidant effects, and their protective effects on H2 O2 -induced damage in human dopaminergic neuroblastoma cells (SH-SY5Y). Compounds3, 6, and7 displayed moderate anti-oxidant activities with IC50 values in the range of 36.9– 40.7 μM. Compound5 showed significant protective activity, while compounds1, 2, 4, 7, and8 showed moderate protective activities.