Efficient one pot multi-component domino Aldol condensation–Michael addition–Suzuki coupling reaction for the highly functionalized quinolines. Issue 33 (12th August 2015)

• Record Type: Journal Article
• Authors: Ubba, Eethamukkala; Kumar, Y. Suneel; Dasaradhan, C.; Khan, Fazlur-Rahman Nawaz; Jeong, Euh Duck; Chung, Eun Hyuk
• Is Part Of: Tetrahedron letters. Volume 56:Issue 33(2015)
• Page Start: 4744
• Page End: 4748
• Publication Date: 2015-08-12
• Subjects: Aldol condensation -- Michael addition -- Suzuki coupling -- PdCl2(PPh3)2/tripotassium phosphate/ethanol–water system; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2015.06.040
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: A parallel and advantageous multi-component one pot reaction has been developed utilizing domino Aldol condensation–Michael addition–Suzuki coupling approach for a variety of 2, 3-disubstituted highly functionalized quinolines. The domino reactions of 2-chloro-3-formylquinolines, 1 acetophenones, 2 and distinctive boronic acids, 3 were carried out utilizing PdCl2 (PPh3 )2 /tripotassium phosphate/ethanol–water system. At 80 °C they gave diversified functionalized quinolines in good yields.