PP.LB02.05: ARTERIAL HYPERTESION. (June 2015)

• Record Type: Journal Article
• Authors: Ramirez, A.J.; Sanchez, R.
• Is Part Of: Journal of hypertension. Volume 33(2015)Supplement 1
• Publication Date: 2015-06
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000468570.50136.78
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Objective: Uric acid is associated with increased cardiovascular diseases and arterial stiffness in chronic renal failure or stroke. However, less information related to the association of uric acid and arterial stiffness in hypertensive subjects. Thus, the aim of the present work was to evaluate the relationship of PWV, uric acid and different metabolic parameters in hypertensive patients. Design and method: We studied 395 subjects (213, male, 55 ± 0.91 years and 180 females, 58 ± 0.97 years) with normal renal function screened from the day hospital evaluation. In each one of them general biochemical laboratory (blood and 24 h urine), cardiac Doppler echography and Carotid-Femoral PWV, was performed. Additionally, 18 hypertensives had a 24hs ambulatory central blood pressure measurement (Mobil O Graph device) with1 h beat to beat blood pressure (BP, Finapres Method) was registered and BP and heart Rate (HR) variability and baroreflex sensitivity calculated. Results: In all subjects studied, no statistical differences were found in age (M: 55 ± 0–91 y; F: 58 ± 0.97 y), BMI (M: 28.85 ± 0, 26 Kg/m2; F: 28.09 ± 0.42 Kg/m2), BP (M: 133.6 ± 0.96/77.87 ± 0.65 mmHg; F: 133.2 ± 1.47 mmHg), PWV (M: 9.16 ± 0.16 m/sec; F: 9.01 ± 0.18 m/sec). In all subjects studied, PWV showed a more significant correlation with uric acid (M: r = 0.92, F: r = 0.92 than SBP (r = 0.25) and age (r = 0.30) but higher with 24hs ambulatory central blood pressure (r = 0.85) and BP variability (r = 0.45). PWV was also significantly related to cardiac hypertrophy (LVMI) only in in all subjects (r = 0.23) and men (r = 0.33). Uric acid showed a significant correlation with markers for metabolic alterations as BMI (All: r = 0.34; F: 0.53, M: 0.21), waist circumference (All: 0.47; F: 0.45; M: 0.30), Glycaemia at 120 min (All: 0.27; F: 0.24; M: 0.38) as to plasmatic Creatinine (All: r = 0.54; F: r = 0.30; M: r = 0.41). Finally. a significant relationship in all subjects and females was found with fasting insulin (All: r = 0.21; F: 0.22), Ins at 120 min: (All: r = 0.23; F: 0.36) and LVMI (All: 0.27; F: 0.28). Conclusions: In this group of hypertensives, levels of serum uric acid represent an independent predictor of stiffness and metabolic alterations, especially in women. The main factors reducing arterial distensibility (PWV) were uric acid, central blood pressure and BP variability.