Targeted Prostate Gland Biopsy With Combined Transrectal Ultrasound, mpMRI, and 18F-FMAU PET/CT. (August 2015)

• Record Type: Journal Article
• Authors: Jadvar, Hossein; Chen, Kai; Ukimura, Osamu
• Is Part Of: Clinical nuclear medicine. Volume 40:Number 8(2015)
• Publication Date: 2015-08
• Subjects: prostate -- cancer -- FMAU -- PET -- ultrasound -- MRI; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000000814
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: We report on a 61-year-old man with elevated serum prostate-specific antigen level of 10.5 ng/mL who had undergone prior negative standard transrectal ultrasound biopsy at another institution. He was referred to our medical center for evaluation and underwent a clinical 3-T multiparametric MRI and a research protocol PET/CT with the cellular proliferation radiotracer 18 F-FMAU (2′-deoxy-2′-[ 18 F]fluoro-5-methyl-1-β-D-arabinofuranosyluracil). The PET/CT and multiparametric MRI were fused with transrectal ultrasound images for real-time hybrid image–based targeting of the biopsy needle. PET/CT with 18 F-FMAU was helpful in localizing the nonstandard biopsy sites that on histopathology revealed suspected tumor deposits.