PP.26.07: RENAL RESISTIVE INDEX IN PATIENTS WITH TRUE RESISTANT HYPERTENSION. (June 2015)

• Record Type: Journal Article
• Authors: Warchol-Celinska, E.; Florczak, E.; Szwench-Pietrasz, E.; Prejbisz, A.; Januszewicz, A.; Michalowska, I.; Kabat, M.; -Sitkowska, H. Janaszek; Januszewicz, M.
• Is Part Of: Journal of hypertension. Volume 33(2015)Supplement 1
• Publication Date: 2015-06
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000468490.82484.21
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Objective: Increased ultrasound doppler renal resistive index (RRI) is a marker of atherosclerotic and hypertensive organ damage both at renal and systemic level. The aim of the study was to evaluate RRI in patients with true resistant hypertension (TRHT) in the Resist-Pol study. Design and method: From 204 patients diagnosed with TRHT in the Resist-Pol study, 151 patients (90 M, 61F, mean age: 47, 7, range: 19–65 ys) without secondary hypertension were included into the analysis. All patients were characterized by estimated glomerular filtration rate (eGFR) > 60 ml/min/1, 73m2 and no history of diabetes prior to the study. As a control group we included 50 age and gender-matched patients (35 M, 15F, mean age: 46, 8, range: 19–65 ys) with primary well-controlled hypertension. The groups did not also differ in respect of the number of years of known history of HT. The RRIs were evaluated on the basis of the doppler ultrasound examination. Increased RRI was defined as > = 0, 7. Results: Patients with TRHT were characterized by higher RRI as compared with the group with well-controlled hypertension (0, 62 ± 0, 05 vs. 0, 60 ± 0, 05, p < 0, 05). The groups did not differ in respect of renal function assessed by creatinine serum concentration (78, 6 ± 17, 7 vs. 81, 1 ± 16, 1 μmol/l, p = 0, 387) and eGFR (92, 2 ± 16, 1 vs. 93, 9 ± 18, 8 ml/min/1, 73m2, p = 0, 539). The increased RRI was found in 7, 3% (11) pts with TRHT and 2% (1) pts with well-controlled hypertension. Among patients with TRHT, patients with the increased RRI were characterized by older age (52, 2 ± 4, 9 vs.47, 3 ± 10, 6 ys, p < 0, 05), higher body mass index (32, 8 ± 6, 0 vs. 29, 7 ± 4, 5 kg/m2, p < 0, 05), as well as lower 24 h, daytime and nighttime diastolic blood pressure values (77, 8 ± 6, 1 vs. 85, 8 ± 12, 9 mmHg, p < 0, 01; 80, 6 ± 7, 7 vs. 89, 8 ± 13, 0 mmHg, p < 0, 05; 72, 1 ± 4, 9 vs. 78, 2 ± 12, 3 mmHg, p < 0, 01, respectively) as compared to patients with RRI < 0, 7. The both groups did not differ in respect of renal function. Conclusions: Our study showed that the patients with TRHT were characterized by higher RRI values as compared to the subjects with well-controlled HT.