Dual‐drug release from chitin‐based core–shell microspheres fabricated by coaxial electrospray. Issue 5 (24th January 2017)

• Record Type: Journal Article
• Authors: Shang, Yu; Ding, Fuyuan; Liu, Jian; Xiao, Ling; Deng, Hongbing; Du, Yumin; Shi, Xiaowen
• Is Part Of: Advances in polymer technology. Volume 37:Issue 5(2018)
• Page Start: 1366
• Page End: 1373
• Publication Date: 2017-01-24
• Subjects: chitin -- coaxial electrospray -- core–shell microspheres -- dual‐drug release; Plastics -- Periodicals; Polymers -- Periodicals; 668.9
• DOI: 10.1002/adv.21795
• Languages: English
• ISSNs: 0730-6679

Abstract

Abstract: Polymeric core–shell microspheres have been widely applied in dual‐drug release system for their convenience to treat diseases through multiple therapies. In this contribution, acrylamide‐modified chitin (AMC)/chitosan (CS) core–shell microspheres were prepared by a coaxial electrospray method under mild conditions. The dimension of the microspheres and thickness of the layer can be delicately controlled by changing the feed rate of spray solutions and the applied voltage. The core–shell structure of the microspheres was characterized by Fourier transform infrared spectra (FT‐IR), scanning electron microscope (SEM), and stereo fluorescence microscope. To investigate the dual‐drug release behavior of the core–shell microspheres, small molecular FITC‐dextran and macromolecular dextran blue 2000 were chosen as model drugs. The release rate of small molecular FITC‐dextran was higher than macromolecular dextran blue 2000 regardless of the location of FITC‐dextran in the microspheres. The biocompatibility, biodegradability, and dual‐drug release behavior of the core–shell microspheres endow it with potential applications in combination therapies.