Relationship between subchondral bone microstructure and articular cartilage in the osteoarthritic knee using 3T MRI. Issue 3 (16th February 2018)

• Record Type: Journal Article
• Authors: Liu, Chenglei; Liu, Chang; Si, Liping; Shen, Hao; Wang, Qian; Yao, Weiwu
• Is Part Of: Journal of magnetic resonance imaging. Volume 48:Issue 3(2018)
• Page Start: 669
• Page End: 679
• Publication Date: 2018-02-16
• Subjects: magnetic resonance imaging (MRI) -- osteoarthritis -- subchondral bone -- knee; Magnetic resonance imaging -- Periodicals; 616
• DOI: 10.1002/jmri.25982
• Languages: English
• ISSNs: 1053-1807

Abstract

Abstract : Background: The importance of subchondral bone in the pathogenesis of osteoarthritis (OA) has drawn interest. Purpose: To investigate subregional trabecular bone microstructural features and to determine the relationship between cartilage and trabecular bone in the osteoarthritic human knee. Study Type: Prospective study. Subjects: In all, 92 knees were enrolled and divided into three groups: without OA, mild OA, and severe OA. Sequence: A sagittal 3D balanced fast field echo (3D B‐FFE) sequence and FatSat 3D fast field echo (3D‐FFE) sequence at 3T MRI. Assessment: The trabecular bone in 12 sites of the knee joint was evaluated using digital topological analysis, and the cartilage thickness in four sites was calculated. Statistical Test: Trabecular bone and cartilage parameters between groups were compared using analysis of variance (ANOVA) with Bonferroni adjustment, and their correlations were analyzed using Pearson's correlation coefficient. Results: Within both femoral condyles, the trabecular bone structure deteriorated in mild OA, showing a lower bone volume fraction (BVF) (0.15 to 0.12, P < 0.05), higher erosion index (EI) (2.25 to 2.28, P < 0.01), and a lower plate‐to‐rod ratio (SCR) (6.22 to 5.96, P < 0.05). Within medial and lateral tibia, deterioration in the trabecular bone was also observed, demonstrating a lower BVF (0.15 to 0.12 P < 0.05) and a higher EI (2.25 to 2.61, P < 0.05). Cartilage attrition mainly occurred in the medial joint. Extensive correlations were found between the medial cartilage thickness and subregional trabecular parameters. There was mainly a positive correlation with both femoral BVFs ( r > 0.3, P < 0.05), and a negative correlation with the tibia SCR ( r < –0.2, P < 0.05). Data Conclusion: In the early stage of OA, trabecular bone osteoporotic changes were observed in both femoral condyles and the tibia. Based on a strong correlation with the medial cartilage thickness, the trabecular structural topological analysis may be useful for elucidating OA onset and progression. Level of Evidence: 2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018;48:669–679.