Why docosapentaenoic acid is not included in the Omega-3 Index. (August 2018)

• Record Type: Journal Article
• Authors: von Schacky, Clemens; Harris, William S.
• Is Part Of: Prostaglandins, leukotrienes, and essential fatty acids. Volume 135(2018)
• Page Start: 18
• Page End: 21
• Publication Date: 2018-08
• Subjects: Docosapentaenoic acid -- Eicosapentaenoic acid -- Docosaehexaenoic acid -- Omega-3 fatty acids; EPA Eicosapentaenoic acid -- DPA Docosapentaenoic acid -- DHA Docosahexaenoic acid; Lipids -- Periodicals; Unsaturated fatty acids -- Periodicals; Prostaglandins -- Periodicals; Leukotrienes -- Periodicals; Fatty Acids, Unsaturated -- Periodicals; Acides gras insaturés -- Périodiques; Prostaglandines -- Périodiques; Leucotriènes -- Périodiques; Lipides -- Périodiques; 612.01577
• DOI: 10.1016/j.plefa.2018.06.003
• Languages: English
• ISSNs: 0952-3278

Abstract

Highlights: The Omega-3 Index is defined as EPA and DHA, but not DPA, in erythrocytes. Whether DPA is a useful addition to the Omega-3 Index is reviewed and discussed. Current scientific evidence does not support including DPA into the Omega-3 Index. Abstract: As currently defined, the Omega-3 Index comprises eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), but not docosapentaenoic acid (DPA) in erythrocytes. In fish and many fish oils DPA is detectable (along with EPA and DHA), but sources rich in DPA are scarce. Purified DPA is available, and DPA is a precursor of biologically active molecules, but much remains to be learned about the effects of DPA in humans. In epidemiologic studies, erythrocyte DPA did not predict risk for total mortality, sudden cardiac death, or other relevant cardiovascular events, and, more importantly, did not improve prediction of these events when included along with EPA and DHA, the original Omega-3 Index. We conclude that current scientific evidence does not support including DPA into the Omega-3 Index.