Ligusaginoids A–D, four eremophilane-type sesquiterpenoid dimers and trimers from Ligularia sagitta. Issue 38 (19th September 2018)

• Record Type: Journal Article
• Authors: Li, Hang-Ying; Zheng, Zai-Qin; Wei, Wen-Jun; Chen, Jian-Jun; Gao, Kun
• Is Part Of: Tetrahedron letters. Volume 59:Issue 38(2018)
• Page Start: 3461
• Page End: 3466
• Publication Date: 2018-09-19
• Subjects: Ligularia sagitta -- Eremophilane -- Sesquiterpenoid -- Structure determination -- Antibacterial activities; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2018.08.009
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Isolation of four novel eremophilane-type sesquiterpenoid dimers and trimers from Ligularia sagitta. The absolute configuration of 1 was confirmed by single crystal X-ray data. The plausible biosynthetic pathway of1 –4 was proposed. Abstract: Four novel highly oxygenated eremophilane-type sesquiterpenoid dimers and trimers with the unique 6/6/5/5 polycyclic skeleton, designated as ligusaginoids A–D (1 –4 ), were isolated from the aerial parts of Ligularia sagitta . Their structures with absolute configurations were determined by a combined method. Moreover, a plausible biosynthetic pathway of1 –4 was also proposed. These compounds showed weak antibacterial activities.