Three new 3-methyl-2-arylbenzofurans from the fermentation products of an endophytic fungus Phomopsis sp. and their anti-TMV activity. (September 2017)

• Record Type: Journal Article
• Authors: Du, Gang; Wang, Zhong-Cheng; Hu, Wei-Yao; Yan, Ke-Liang; Wang, Xin-Lin; Yang, Hong-Mei; Yang, Hai-Ying; Gao, Yu-Hong; Liu, Qiang; Hu, Qiu-Fen
• Is Part Of: Phytochemistry letters. Volume 21(2017:Sep.)
• Page Start: 287
• Page End: 290
• Publication Date: 2017-09
• Subjects: Arylbenzofurans -- Phomopsis sp -- Anti-tobacco mosaic virus activity; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2016.04.003
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: Three new (1 –3 ) and four known (4 –7 ) arylbenzofurans were isolated. Compounds1–7 were evaluated for their anti-TMV and antibacterial activities. Compound3 exhibit high anti-TMV activities with inhibition rates of 35.2%. All compounds do not exhibit antibacterial activities. Abstract: Three new arylbenzofurans, 7-methoxy-2-(4-methoxyphenyl)-3-methyl-5-(3-prenyl)-benzofuran (1 ), 2-(4-methoxyphenyl)-3-methyl-5-(3-prenyl)-benzofuran-7-ol (2 ), 2-(4-hydroxy-3, 5-dimethoxyphenyl)-3-methyl-5-(3-prenyl)benzofuran-7-ol (3 ), along with four known arylbenzofurans (4 –7 ) were isolated from the fermentation products of an endophytic Phomopsis sp. Their structures were elucidated by spectroscopic methods including extensive 1D- and 2D-NMR techniques. In addition, compounds1 –7 were tested for their anti-tobacco mosaic virus (anti-TMV) activity. The results showed that compound3 exhibited obvious anti-TMV activity with inhibition rate of 35.2% better than that of positive control (31.8%). The other compounds also showed potential anti-TMV activity with inhibition rates in the range of 18.6–25.7%, respectively.