Transfusion transmission of hepatitis A virus with fecal shedding in a previously hepatitis A vaccinated recipient. Issue 9 (September 2018)

• Record Type: Journal Article
• Authors: Vestergaard, Hanne Thang; Harritshøj, Lene Holm; Midgley, Sofie Elisabeth; Ullum, Henrik; Kampmann, Peter
• Is Part Of: Journal of infection and chemotherapy. Volume 24:Issue 9(2018:Sep.)
• Page Start: 766
• Page End: 768
• Publication Date: 2018-09
• Subjects: Hepatitis A shedding -- Transfusion transmission -- Transient infection -- Post-exposure prophylaxis; Chemotherapy -- Periodicals; Infection -- Periodicals; Communicable diseases -- Chemotherapy -- Periodicals; 615.5805
• DOI: 10.1016/j.jiac.2018.01.020
• Languages: English
• ISSNs: 1341-321X

Abstract

Abstract: We describe a rare case of hepatitis A virus (HAV) replication in feces despite presence of hepatitis A antibodies in an acute myeloid leukemia (AML) patient after transfusion with HAV contaminated platelets. The patient has been vaccinated against HAV years before the AML diagnosis. Transient infection and reshedding should thus be considered in antibody-positive hematological patients. Transfusion associated HAV transmission is rare, and little evidence exists on the clinical consequences and possible effect of treatment with immunoglobulin. Further reporting on fecal shedding despite antibodies are needed, as HAV antibody levels are used as course of action for post-exposure prophylaxis and infection control.